IDWeek 2018

Pooled safety data of eravacycline in 3 comparator-controlled studies for the treatment of complicated intra-abdominal infections showed that it was generally well-tolerated compared with ertapenem and meropenem.
A pooled analysis showed favorable safety results from phase 3 studies of omadacycline, a new once-daily intravenous/oral therapy for the monotherapy of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections.
Identifying social vulnerabilities that likely impact pediatric outpatient antimicrobial treatment after discharge could better enable treatment customization or prompt care coordination.
A protocol to guide rational antibiotic therapy in patients receiving extracorporeal membrane oxygenation can lead to a reduction in the use of specific antibiotics, but paradoxically, may increase overall antibiotic use.
In patients with community-acquired pneumonia, a regimen that includes a fluoroquinolone (and possibly a macrolide) may reduce mortality compared with beta-lactams (with or without a beta-lactamase inhibitor) and cephalosporins alone.
Evaluation of lefamulin, a novel oral antimicrobial, in patients with community-acquired bacterial pneumonia demonstrated noninferiority for both the US Food and Drug Administration and European Medicines Agency efficacy end points versus oral moxifloxacin.
Although community-acquired pneumonia (CAP) guidelines recommend transition to an oral beta-lactam regimen or fluoroquinolone (FQ) when patients are clinically stable, the collateral damage associated with FQ usage has led stewardship efforts to reduce initial FQ usage in CAP therapy.
A successful antibiotic stewardship intervention can reduce the usage of fluoroquinolones for patient safety and resistance concerns in community-acquired pneumonia.
The researchers assessed the impact of antimicrobial stewardship program interventions in elderly patients on 30-day readmissions due to treatment failure and decreased antibiotic expenditures per adjusted patient-day.
Shortening the duration of antimicrobial therapy to that recommended in guidelines may reduce the risk for collateral damage due to Clostridium difficile infection.
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