Conference Correspondent

ASH 2016 - Multiple Myeloma

In this analysis, researchers evaluate whether daratumumab can further reduce minimal residual disease when added to lenalidomide- and bortezomib-containing regimens in patients with relapsed/refractory multiple myeloma.

Researchers conducted a systematic literature review and subsequent meta-analysis of progression-free survival outcomes to compare 16 different treatment regimens for relapsed/refractory multiple myeloma.

In an effort to determine whether lower peripheral neuropathy rates could be achieved, this study evaluated the efficacy and safety of subcutaneous bortezomib in combination with lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma.

Payers have expressed concern about the rising costs of combination therapies in multiple myeloma. In an effort to address these potential concerns, a budget impact model was developed to estimate the 3-year costs of adding elotuzumab in combination with lenalidomide and dexamethasone to a health plan’s formulary.

Risk stratification tools are used to estimate survival expectations and help to guide treatment decisions after first relapse in multiple myeloma. European researchers have developed a new stratification tool consisting of 4 distinct dimensions that are used to characterize risk of survival.

Immunotherapy is being studied as a potential treatment approach in a variety of hematologic malignancies. Here, researchers present the findings of a phase 2 trial evaluating pembrolizumab in combination with pomalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma.

Unmet treatment needs remain in multiple myeloma, particularly among patients with relapsed/refractory disease who have received multiple lines of therapy. This study evaluates a potential salvage approach of daratumumab-based retreatment in patients refractory to daratumumab and/or pomalidomide.

PREAMBLE (Prospective Research Assessment in Multiple Myeloma: An Observational Evaluation) is an ongoing multinational observational study being conducted to evaluate real-world outcomes in patients with multiple myeloma. Here, researchers present preliminary efficacy analyses in patients with one line of prior therapy.

Novel triplet combinations are being evaluated in both the newly diagnosed and relapsed/refractory settings in multiple myeloma. This study evaluates the efficacy and safety of ixazomib, pomalidomide, and dexamethasone combination therapy in a heavily pretreated, high-risk patient population.

Payers seek to understand the value of myeloma treatment options by assessing outcomes relative to cost. This claims-based analysis assesses trends in novel therapy use, total healthcare costs, and survival outcomes among newly diagnosed multiple myeloma patients in the United States since 2000.

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